26.11 Red cell folate

Red cell folate data available for STOP cohort only.


26.11.1 Global tests

Type III ANOVA on main and interaction effects, and LM model summaries.

PRL (ng/ml)
Chisq Df Pr(>Chisq)
(Intercept) 43.64894 1 <0.0001 ***
ns(rcfolate, 3) 5.76169 3 0.1 ns
GA_samp 70.48397 1 <0.0001 ***
hPL (μg/ml)
Chisq Df Pr(>Chisq)
(Intercept) 10.1918551 1 0.001 **
ns(rcfolate, 3) 0.1840576 3 1.0 ns
GA_samp 1109.0784596 1 <0.0001 ***
GH2 (ng/ml)
Chisq Df Pr(>Chisq)
(Intercept) 94.062933 1 <0.0001 ***
ns(rcfolate, 3) 6.776213 3 0.08 ns
GA_samp 558.762160 1 <0.0001 ***
Insulin (uU/ml)
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.363 0.363 0.5 ns
GA_samp 1 Inf 0.389 0.389 0.5 ns
HOMA-IR
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.345 0.345 0.6 ns
GA_samp 1 Inf 0.266 0.266 0.6 ns
Glucose (mmol/L)
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.171 0.171 0.7 ns
GA_samp 1 Inf 1.236 1.236 0.3 ns

26.11.2 Model summary

Ratio of Geometric means (95% CI)

PRL (ng/ml)
Var Effect P
(Intercept) 17.37 (7.46, 40.43) <0.0001
ns(rcfolate, 3)1 0.80 (0.49, 1.32) 0.39
ns(rcfolate, 3)2 0.89 (0.18, 4.41) 0.89
ns(rcfolate, 3)3 1.01 (0.80, 1.27) 0.92
GA_samp 1.15 (1.11, 1.18) <0.0001
hPL (μg/ml)
Var Effect P
(Intercept) 2.13 (1.34, 3.40) 0.001
ns(rcfolate, 3)1 0.95 (0.72, 1.25) 0.72
ns(rcfolate, 3)2 0.87 (0.36, 2.10) 0.75
ns(rcfolate, 3)3 0.99 (0.87, 1.12) 0.86
GA_samp 1.35 (1.33, 1.37) <0.0001
GH2 (ng/ml)
Var Effect P
(Intercept) 0.04 (0.02, 0.08) <0.0001
ns(rcfolate, 3)1 0.93 (0.64, 1.37) 0.73
ns(rcfolate, 3)2 1.52 (0.44, 5.27) 0.51
ns(rcfolate, 3)3 0.90 (0.75, 1.07) 0.24
GA_samp 1.35 (1.32, 1.38) <0.0001
Insulin (uU/ml)
Var Effect P
(Intercept) 11.14 (4.71, 26.36) <0.0001
ns(rcfolate, 3)1 0.80 (0.48, 1.31) 0.37
ns(rcfolate, 3)2 0.65 (0.13, 3.15) 0.59
ns(rcfolate, 3)3 1.07 (0.85, 1.35) 0.57
GA_samp 1.01 (0.97, 1.06) 0.53
HOMA-IR
Var Effect P
(Intercept) 2.42 (0.93, 6.32) 0.07
ns(rcfolate, 3)1 0.79 (0.45, 1.38) 0.41
ns(rcfolate, 3)2 0.63 (0.10, 3.76) 0.61
ns(rcfolate, 3)3 1.09 (0.85, 1.40) 0.50
GA_samp 1.01 (0.97, 1.06) 0.61
Glucose (mmol/L)
Var Effect P
(Intercept) 5.04 (4.04, 6.30) <0.0001
ns(rcfolate, 3)1 1.00 (0.88, 1.13) 1.00
ns(rcfolate, 3)2 0.96 (0.60, 1.52) 0.86
ns(rcfolate, 3)3 1.06 (1.00, 1.13) 0.05
GA_samp 1.00 (0.99, 1.00) 0.27

26.11.3 Diagnostics

Model diagnositcs.

Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)

26.11.4 Plots